First Human Trial of High-Frequency Irreversible Electroporation Therapy for Prostate Cancer
نویسندگان
چکیده
منابع مشابه
Finite Element Analysis of Tissue Conductivity during High-frequency and Low-voltage Irreversible Electroporation
Introduction: Irreversible electroporation (IRE) is a process in which the membrane of the cancer cells are irreversibly damaged with the use of high-intensity electric pulses, which in turn leads to cell death. The IRE is a non-thermal way to ablate the cancer cells. This process relies on the distribution of the electric field, which affects the pulse amplitude, width, and electrical conducti...
متن کاملA prospective development study investigating focal irreversible electroporation in men with localised prostate cancer: Nanoknife Electroporation Ablation Trial (NEAT)
INTRODUCTION Focal therapy may reduce the toxicity of current radical treatments while maintaining the oncological benefit. Irreversible electroporation (IRE) has been proposed to be tissue selective and so might have favourable characteristics compared to the currently used prostate ablative technologies. The aim of this trial is to determine the adverse events, genito-urinary side effects and...
متن کاملIrreversible electroporation: a novel image-guided cancer therapy.
Irreversible electroporation (IRE) is a novel tumor ablation technique using a non-thermal energy to create innumerable permanent nanopores in the cell membrane to disrupt cellular homeostasis. This disruption of cellular homeostasis initiates apoptosis which leads to permanent cell death. In our translational research, we have demonstrated that IRE can be a safe, fast and powerful method of tu...
متن کاملMRI-TRUS fusion for electrode positioning during irreversible electroporation for treatment of prostate cancer.
We aimed to introduce an approach for image-guided positioning of electrodes for irreversible electroporation (IRE) in patients with prostate cancer using a magnetic resonance imaging-transrectal ultrasonography (MRI-TRUS) fusion technique. In 10 consecutive patients with biopsy-proven Gleason score ≤3+4 prostate cancer, 19 G electrodes were inserted into the prostate using a transperineal acce...
متن کاملHigh-frequency irreversible electroporation (H-FIRE) for non-thermal ablation without muscle contraction
BACKGROUND Therapeutic irreversible electroporation (IRE) is an emerging technology for the non-thermal ablation of tumors. The technique involves delivering a series of unipolar electric pulses to permanently destabilize the plasma membrane of cancer cells through an increase in transmembrane potential, which leads to the development of a tissue lesion. Clinically, IRE requires the administrat...
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ژورنال
عنوان ژورنال: Technology in Cancer Research & Treatment
سال: 2018
ISSN: 1533-0346,1533-0338
DOI: 10.1177/1533033818789692